Gao_Mza

Contributors: Hugo Vaysset

Description

Mza (MutL, Z1, DUF, AIPR) is a defense system composed of five proteins. Its antiphage activity was assessed by heterologous expression in E. coli against phages T2, T4, T5, lambda and M13 (ssDNA phage) () .

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Gao_Mza is composed of 5 proteins: MzaA, MzaB, MzaC, MzaD and MzaE.

Here is an example found in the RefSeq database:

The Gao_Mza system in Massilia sp. Se16.2.3 (GCF_014171595.1, NZ_CP050451) is composed of 6 proteins MzaA (WP_182990577.1) MzaB (WP_229425381.1) MzaC (WP_182990578.1) MzaD (WP_182990579.1) MzaE (WP_182990580.1) MzaE (WP_182990581.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Gao_Mza is detected in 68 genomes (0.3 %).

The system was detected in 32 different species.

Proportion of genome encoding the Gao_Mza system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Gao_Mza

Example 1

Experimental validation

      
graph LR;
    Gao_2020[Gao et al., 2020] --> Origin_0
    Origin_0[Salmonella enterica 
VEA06816.1, VEA06814.1,
VEA06812.1, VEA06810.1,
VEA06808.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T2 & T4 & T5 & Lambda & M13
    subgraph Title1[Reference]
        Gao_2020
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T2
        T4
        T5
        Lambda
        M13
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1126/science.aba0372
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