Gao_Ppl

Contributors: Florian Tesson

Description

Gao_Ppl or Ppl system is a single gene system. This system was discovered among others in () . This single gene system is described with 2 different domains: PHP (Polymerase and Histidinol Phosphatase) which is a putative nuclease and an ATPase domain.

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Gao_Ppl is composed of 1 protein: PplA.

Here is an example found in the RefSeq database:

The Gao_Ppl system in Enterobacter sp. E76 (GCF_008931465.1, NZ_CP042499) is composed of 1 protein: PplA (WP_032676599.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Gao_Ppl is detected in 276 genomes (1.21 %).

The system was detected in 104 different species.

Proportion of genome encoding the Gao_Ppl system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Gao_Ppl

Example 1

Experimental validation

      
graph LR;
    Gao_2020[Gao et al., 2020] --> Origin_0
    Origin_0[Salmonella enterica 
STM52149.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> Lambda & T3 & T7 & PhiV-1
    subgraph Title1[Reference]
        Gao_2020
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        Lambda
        T3
        T7
        PhiV-1
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1126/science.aba0372
no authors
no containerTitle ()