Gao_RL

Contributors: Aude Bernheim

Description

The Gao_RL system is composed of 4 proteins: RL_D, RL_C, RL_B and, RL_A. It bears similarity with restriction systems ()

Molecular Mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Gao_RL is composed of 4 proteins: RL_A, RL_B, RL_C and RL_D.

Here is an example found in the RefSeq database:

The Gao_RL system in Methylocystis heyeri (GCF_004802635.2, NZ_CP046053) is composed of 4 proteins RL_A (WP_136498122.1) RL_B (WP_136498123.1) RL_C (WP_154331773.1) RL_D (WP_136498124.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Gao_RL is detected in 131 genomes (0.57 %).

The system was detected in 74 different species.

Proportion of genome encoding the Gao_RL system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Gao_RL

Example 1

Experimental validation

      
graph LR;
    Gao_2020[Gao et al., 2020] --> Origin_0
    Origin_0[Escherichia coli 
WP_000860009.1, WP_001044652.1,
WP_001207938.1, WP_000985714.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> P1 & Lambda & M13
    subgraph Title1[Reference]
        Gao_2020
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        P1
        Lambda
        M13
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1126/science.aba0372
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