Gao_upx

Contributors: Marian Dominguez-Mirazo

Description

The Gao_upx system is composed of a single protein. It was predicted through a guilty-by-association approach independent of domain annotations and validated in a heterologous system () . It's been identified as part of a highly conserved core defense hotspot in Pseudomonas aeruginosa strains () .

Molecular mechanisms

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Gao_Upx is composed of 1 protein: UpxA.

Here is an example found in the RefSeq database:

The Gao_Upx system in Serratia sp. JSRIV001 (GCF_019968745.1, NZ_CP074147) is composed of 1 protein: UpxA (WP_223499068.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Gao_Upx is detected in 39 genomes (0.17 %).

The system was detected in 33 different species.

Proportion of genome encoding the Gao_Upx system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Gao_Upx

Example 1

Experimental validation

      
graph LR;
    Gao_2020[Gao et al., 2020] --> Origin_0
    Origin_0[Escherichia coli 
WP_060647174.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> P1 & PhiV-1
    subgraph Title1[Reference]
        Gao_2020
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        P1
        PhiV-1
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1126/science.aba0372
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10.1093/nar/gkad317
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