Menshen

Contributors: Alba Herrero del Valle

Description

The Menshen system has been identified by Millman et al. as a three-protein system NsnA, NsnB and NsnC. Menshen from Solibacillus silvestris StLB046 confers resistance in E. coli and B. subtilis against some phages () .

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Menshen is composed of 3 proteins: NsnA, NsnB and NsnC.

Here is an example found in the RefSeq database:

The Menshen system in Streptomyces marincola (GCF_020410765.1, NZ_CP084541) is composed of 3 proteins NsnA (WP_226077564.1) NsnB (WP_226077566.1) NsnC_2507451963 (WP_226077568.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Menshen is detected in 430 genomes (1.89 %).

The system was detected in 263 different species.

Proportion of genome encoding the Menshen system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Menshen

Example 1

Experimental validation

      
graph LR;
    Millman_2022[Millman et al., 2022] --> Origin_0
    Origin_0[Solibacillus silvestris 
2562294789, 2562294790,
2562294791] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T2 & T4 & T6
    Millman_2022[Millman et al., 2022] --> Origin_0
    Origin_0[Solibacillus silvestris 
2562294789, 2562294790,
2562294791] --> Expressed_1[Bacillus subtilis]
    Expressed_1[Bacillus subtilis] ----> Fado
    subgraph Title1[Reference]
        Millman_2022
end
    subgraph Title2[System origin]
        Origin_0
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
        Expressed_1
end
    subgraph Title4[Protects against]
        T2
        T4
        T6
        Fado
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1016/j.chom.2022.09.017
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