Panchino_gp28

Contributors: Lucas Paoli

Description

The Panchino gp28 defense system was described in () and is named after the Panchino prophage (on which it is located) and the corresponding gene. It is a single-gene system.

Molecular mechanisms

Panchino gp28 acts as a single gene type I restriction system (, ) .

Example of genomic structure

The Panchino_gp28 is composed of 1 protein: gp28.

Here is an example found in the RefSeq database:

The Panchino_gp28 system in Burkholderia pseudomallei (GCF_018228585.1, NZ_CP073731) is composed of 1 protein: gp28 (WP_249212015.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Panchino_gp28 is detected in 16 genomes (0.07 %).

The system was detected in 5 different species.

Proportion of genome encoding the Panchino_gp28 system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Panchino_gp28

Example 1

Experimental validation

      
graph LR;
    Dedrick_2017[Dedrick et al., 2017] --> Origin_0
    Origin_0[Mycobacterium Panchino phage 
YP_009304936.1] --> Expressed_0[Mycobacterium smegmatis mc2 155]
    Expressed_0[Mycobacterium smegmatis mc2 155] ----> Tweety & TM4 & Bruita & U2 & 244
    subgraph Title1[Reference]
        Dedrick_2017
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        Tweety
        TM4
        Bruita
        U2
        244
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1038/nmicrobiol.2016.251
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10.1016/j.mib.2023.102321
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