PD-Lambda-3

Contributors: Héloïse Georjon

Description

PD-Lambda-3 systems were discovered to be anti-phage systems during an experimental screen performed on E.coli ()

Molecular mechanisms

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The PD-Lambda-3 is composed of 2 proteins: PD-Lambda-3_A and PD-Lambda-3_B.

Here is an example found in the RefSeq database:

The PD-Lambda-3 system in Enterobacter sp. CRENT-193 (GCF_002787395.1, NZ_CP024812) is composed of 2 proteins PD-Lambda-3_A (WP_001542736.1) PD-Lambda-3_B (WP_039268887.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the PD-Lambda-3 is detected in 72 genomes (0.32 %).

The system was detected in 28 different species.

Proportion of genome encoding the PD-Lambda-3 system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

PD-Lambda-3

Example 1

Experimental validation

      
graph LR;
    Vassallo_2022[Vassallo et al., 2022] --> Origin_0
    Origin_0[Escherichia coli 
RCP74640.1, RCP74641.1,
RCP74642.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> LambdaVir
    subgraph Title1[Reference]
        Vassallo_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        LambdaVir
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1038/s41564-022-01219-4
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