PD-Lambda-5

Contributors: Nathalie Bechon

Description

PD-lambda-5 is a two-gene system identified in a P2-like prophage. It encodes a protein with a nuclease and a HEPN domain, and a predicted methyltransferase. It confers broad anti-phage defense and does not seem to mediate abortive infection.

##Molecular mechanism PD-lambda-5 molecular mechanism has not been described to date. It confers protection against a broad range of phages and does not seem to be an abortive infection system.

Example of genomic structure

The PD-Lambda-5 is composed of 2 proteins: PD-Lambda-5_A and PD-Lambda-5_B.

Here is an example found in the RefSeq database:

The PD-Lambda-5 system in Plantactinospora sp. BB1 (GCF_003030385.1, NZ_CP028159) is composed of 2 proteins PD-Lambda-5_A (WP_159104731.1) PD-Lambda-5_B (WP_199853739.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the PD-Lambda-5 is detected in 286 genomes (1.25 %).

The system was detected in 186 different species.

Proportion of genome encoding the PD-Lambda-5 system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

PD-Lambda-5

Example 1

Experimental validation

      
graph LR;
    Vassallo_2022[Vassallo et al., 2022] --> Origin_0
    Origin_0[Escherichia coli 
RCQ13837.1, RCQ13838.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T2 & T4 & T6 & LambdaVir & SECphi17 & SECphi18 & SECphi27 & T3 & T7
    subgraph Title1[Reference]
        Vassallo_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T2
        T4
        T6
        LambdaVir
        SECphi17
        SECphi18
        SECphi27
        T3
        T7
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1038/s41564-022-01219-4
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