PD-T4-4

Contributors: Nathalie Bechon

Description

PD-T4-4 is a defense system composed of two proteins, a P-loop NTPase and a nuclease, that is most likely protecting the bacterial population through abortive infection. It was identified from an ICE in an E. coli genome.

Molecular mechanisms

PD-T4-4 molecular mechanism is currently unknown, although it is most likely an abortive infection system.

Example of genomic structure

The PD-T4-4 is composed of 2 proteins: PD-T4-4_A and PD-T4-4_B.

Here is an example found in the RefSeq database:

The PD-T4-4 system in Thiothrix subterranea (GCF_016772315.1, NZ_CP053482) is composed of 2 proteins PD-T4-4_A (WP_202716711.1) PD-T4-4_B (WP_202716712.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the PD-T4-4 is detected in 50 genomes (0.22 %).

The system was detected in 37 different species.

Proportion of genome encoding the PD-T4-4 system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

PD-T4-4

Example 1

Experimental validation

      
graph LR;
    Vassallo_2022[Vassallo et al., 2022] --> Origin_0
    Origin_0[Escherichia coli 
RCO57999.1, RCO57988.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T2 & T4 & T6 & SECphi17
    subgraph Title1[Reference]
        Vassallo_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T2
        T4
        T6
        SECphi17
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1038/s41564-022-01219-4
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