PD-T4-7

Contributors: Ernest Mordret

Description

PD-T4-7 is a single gene system. Its protein contains a RelE domain and a phage Sheath. protect against T2,T4,T6

Molecular mechanism

Vassalo et al. () state that PD-T4-7 functions through an abortive infection mechanism.

Example of genomic structure

The PD-T4-7 is composed of 1 protein: PD-T4-7.

Here is an example found in the RefSeq database:

The PD-T4-7 system in Thalassospira sp. B30-1 (GCF_015767575.1, NZ_CP065232) is composed of 1 protein: PD-T4-7 (WP_139190007.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the PD-T4-7 is detected in 155 genomes (0.68 %).

The system was detected in 100 different species.

Proportion of genome encoding the PD-T4-7 system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

PD-T4-7

Example 1

Experimental validation

      
graph LR;
    Vassallo_2022[Vassallo et al., 2022] --> Origin_0
    Origin_0[Escherichia coli 
RRN43039.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T2 & T4 & T6
    subgraph Title1[Reference]
        Vassallo_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T2
        T4
        T6
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1038/s41564-022-01219-4
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