PD-T7-1

Contributors: Hugo Vaysset

Description

PD-T7-1 is a single gene defense system that was discovered in () . Its antiphage activity was assessed in E. coli and it was shown to be active against T7.

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The PD-T7-1 is composed of 1 protein: PD-T7-1.

Here is an example found in the RefSeq database:

The PD-T7-1 system in Klebsiella sp. P1927 (GCF_018204675.1, NZ_CP073377) is composed of 1 protein: PD-T7-1 (WP_004150873.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the PD-T7-1 is detected in 748 genomes (3.28 %).

The system was detected in 146 different species.

Proportion of genome encoding the PD-T7-1 system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

PD-T7-1

Example 1

Experimental validation

      
graph LR;
    Vassallo_2022[Vassallo et al., 2022] --> Origin_0
    Origin_0[Escherichia coli 
RCQ85672.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T7
    subgraph Title1[Reference]
        Vassallo_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T7
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1038/s41564-022-01219-4
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