RnlAB

Contributors: Lucas Paoli

Description

RnlAB is a type II toxin-antitoxin system, in which RnlA is the toxin and RnlB the antitoxin () .

Molecular mechanisms

The RnlA toxin has an RNase activity. RnlB (formerly yfjO) is the antitoxin and suppresses the RNase LS activity () .

Example of genomic structure

The RnlAB is composed of 2 proteins: RnlA and RnlB.

Here is an example found in the RefSeq database:

The RnlAB system in Bacteroides caecimuris (GCF_001688725.2, NZ_CP015401) is composed of 2 proteins RnlA (WP_004327332.1) RnlB (WP_004327330.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the RnlAB is detected in 279 genomes (1.22 %).

The system was detected in 68 different species.

Proportion of genome encoding the RnlAB system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

RnlAB

Example 1

Experimental validation

      
graph LR;
    Koga_2011[Koga et al., 2011] --> Origin_0
    Origin_0[Escherichia coli] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T4
    subgraph Title1[Reference]
        Koga_2011
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T4
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1534/genetics.110.121798
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