RosmerTA

Contributors: Lucas Paoli, Gemma Atkinson

Description

The RosmerTA system was found to have antiviral activity and was named after the Gallo-Roman goddess of fertility by Millman et al. 2022 () .

Molecular mechanisms

The RosmerTA system encodes a Zn-peptidase and a toxin of unknown function () . One toxin representative has been found to induce membrane depolarization () .

Example of genomic structure

The RosmerTA is composed of 2 proteins: RmrT and RmrA. The toxin can vary in sequence and structure.

Here is an example found in the RefSeq database:

The RosmerTA system in Paucibacter sp. KCTC 42545 (GCF_001477625.1, NZ_CP013692) is composed of 2 proteins RmrT_2662548665 (WP_231741552.1) RmrA_2662548665 (WP_058719324.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the RosmerTA is detected in 2080 genomes (9.12 %).

The system was detected in 613 different species.

Proportion of genome encoding the RosmerTA system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

RosmerTA

Example 1

Experimental validation

      
graph LR;
    Millman_2022[Millman et al., 2022] --> Origin_0
    Origin_0[Escherichia coli 
2658042940, 2658042941] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> P1 & LambdaVir
    Ernits_2023[Ernits et al., 2023] --> Origin_1
    Origin_1[Gordonia phage Kita 
YP_009301394.1, YP_009301394.1] --> Expressed_1[Escherichia coli]
    Expressed_1[Escherichia coli] ----> Bas54 & Bas59
    subgraph Title1[Reference]
        Millman_2022
        Ernits_2023
end
    subgraph Title2[System origin]
        Origin_0
        Origin_1
end
    subgraph Title3[Expression species]
        Expressed_0
        Expressed_1
end
    subgraph Title4[Protects against]
        P1
        LambdaVir
        Bas54
        Bas59
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1016/j.chom.2022.09.017
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10.1073/pnas.2305393120
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