Rst_3HP

Contributors: Alba Herrero del Valle

Description

The Rst_3HP system is composed of 3 proteins: Hp1, Hp2 and, Hp3. These proteins do not have clear predicted domains but they confer resistance against the phage P1 in Escherichia coli E1114 () .

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Rst_3HP is composed of 3 proteins: Hp1, Hp2 and Hp3.

Here is an example found in the RefSeq database:

The Rst_3HP system in Aquitalea denitrificans (GCF_009856625.1, NZ_CP047241) is composed of 3 proteins Hp1 (WP_159879082.1) Hp2 (WP_159879084.1) Hp3 (WP_159879086.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Rst_3HP is detected in 417 genomes (1.83 %).

The system was detected in 89 different species.

Proportion of genome encoding the Rst_3HP system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Rst_3HP

Example 1

Experimental validation

      
graph LR;
    Rousset_2022[Rousset et al., 2022] --> Origin_0
    Origin_0[Escherichia coli P2 loci 
WP_000508501.1, WP_112026686.1,
WP_000756244.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> P1
    subgraph Title1[Reference]
        Rousset_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        P1
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1016/j.chom.2022.02.018
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