Rst_DUF4238

Contributors: Ernest Mordret

Description

Rst_DUF4238 is a single gene system found in a screen of phage and phage-satellites antiviral hotspots () . It was shown to provide E.coli with a strong resistance against phage T7.

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Rst_DUF4238 is composed of 1 protein: DUF4238.

Here is an example found in the RefSeq database:

The Rst_DUF4238 system in Novosphingobium pentaromativorans (GCF_000767465.1, NZ_CP009291) is composed of 1 protein: DUF4238_Pers (WP_007011908.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Rst_DUF4238 is detected in 46 genomes (0.2 %).

The system was detected in 37 different species.

Proportion of genome encoding the Rst_DUF4238 system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Rst_DUF4238

Example 1

Experimental validation

      
graph LR;
    Rousset_2022[Rousset et al., 2022] --> Origin_0
    Origin_0[Escherichia coli P2 loci 
EGB68990.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T7
    subgraph Title1[Reference]
        Rousset_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T7
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1016/j.chom.2022.02.018
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