Rst_TIR-NLR

Contributors: Lucas Paoli

Description

The Rst_TIR-NLR system is named after the first author of the paper describing it (Rousset et al. 2022) and the domains of the only protein it contains (TIR, toll-interleukin-1 receptor, and NLR, nucleotide-binding leucine-rich repeat receptor) () .

This system is very similar to other bacterial defense systems: bNACHT (https://defense-finder.pasteur.cloud/wiki/defense-systems/nlr), CARD_NLR (https://defense-finder.pasteur.cloud/wiki/defense-systems/card_nlr), Avs (AVAST) (https://defense-finder.pasteur.cloud/wiki/defense-systems/avs).

Molecular mechanisms

As far as we are aware, the molecular mechanism is unknown. However, the molecular mechanism of closely related systems was previously studied. See bNACHT (https://defense-finder.pasteur.cloud/wiki/defense-systems/nlr), CARD_NLR (https://defense-finder.pasteur.cloud/wiki/defense-systems/card_nlr) and Avs (AVAST) (https://defense-finder.pasteur.cloud/wiki/defense-systems/avs)

Example of genomic structure

The Rst_TIR-NLR is composed of 1 protein: TIR.

Here is an example found in the RefSeq database:

The Rst_TIR-NLR system in Methylosinus sp. C49 (GCF_009936375.1, NZ_AP022332) is composed of 1 protein: TIR (WP_161914415.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Rst_TIR-NLR is detected in 233 genomes (1.02 %).

The system was detected in 42 different species.

Proportion of genome encoding the Rst_TIR-NLR system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Rst_TIR-NLR

Example 1

Experimental validation

      
graph LR;
    Rousset_2022[Rousset et al., 2022] --> Origin_0
    Origin_0[Klebsiella pneumoniae P4 loci 
WP_044784989.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T4 & P1 & CLB_P2 & LF82_P8 & AL505_P2 & T7
    subgraph Title1[Reference]
        Rousset_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T4
        P1
        CLB_P2
        LF82_P8
        AL505_P2
        T7
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1016/j.chom.2022.02.018
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