SspBCDE

Example of genomic structure

The SspBCDE is composed of 7 proteins: SspB, SspC, SspD, SspE, SspF, SspG and SspH.

Here is an example found in the RefSeq database:

The SspBCDE system in Vibrio fluvialis (GCF_018140575.1, NZ_CP073273) is composed of 6 proteins SspB (WP_050492436.1) SspC (WP_212571168.1) SspD (WP_032481030.1) SspF (WP_212571169.1) SspG (WP_212571170.1) SspH (WP_212571171.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the SspBCDE is detected in 578 genomes (2.53 %).

The system was detected in 299 different species.

Proportion of genome encoding the SspBCDE system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

SspBCDE

Example 1
Example 2

Experimental validation

      
graph LR;
    Xiong_2020[Xiong et al., 2020] --> Origin_0
    Origin_0[ SspABCD+SspE
Vibrio cyclitrophicus 
WP_022570853.1, WP_016789109.1,
WP_016789110.1, WP_016789111.1,
WP_016789113.1, WP_016789114.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T4 & T1 & JMPW1 & JMPW2 & EEP & T7
    Xiong_2020[Xiong et al., 2020] --> Origin_1
    Origin_1[ SspBCD+SspE
Escherichia coli 
WP_000429341.1, WP_000928407.1,
WP_000840786.1, WP_001424009.1] --> Expressed_1[Escherichia coli]
    Expressed_1[Escherichia coli] ----> T4 & T1 & JMPW1 & JMPW2 & EEP & T7 & PhiX174
    Xiong_2020[Xiong et al., 2020] --> Origin_2
    Origin_2[ SspBCD+SspE
Streptomyces yokosukanensis
WP_067135675.1, WP_037642090.1,
WP_208614377.1, WP_067135521.1,
WP_067135523.1] --> Expressed_2[Streptomyces lividans]
    Expressed_2[Streptomyces lividans] ----> JXY1
    Wang_2021[Wang et al., 2021] --> Origin_3
    Origin_3[ SspBCD+SspFGH
Vibrio anguillarum 
WP_022570853.1, WP_016789109.1,
WP_016789110.1, WP_016789111.1,
WP_017048669.1, ,
WP_017048667.1, WP_017048666.1,
WP_017048665.1, WP_017048664.1] --> Expressed_3[Escherichia coli]
    Expressed_3[Escherichia coli] ----> T1 & JMPW2 & T4 & EEP
    subgraph Title1[Reference]
        Xiong_2020
        Wang_2021
end
    subgraph Title2[System origin]
        Origin_0
        Origin_1
        Origin_2
        Origin_3
end
    subgraph Title3[Expression species]
        Expressed_0
        Expressed_1
        Expressed_2
        Expressed_3
end
    subgraph Title4[Protects against]
        T4
        T1
        JMPW1
        JMPW2
        EEP
        T7
        T4
        T1
        JMPW1
        JMPW2
        EEP
        T7
        PhiX174
        JXY1
        T1
        JMPW2
        T4
        EEP
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1128/mBio.00613-21
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10.1128/mBio.00613-21
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