Tiamat

Contributors: Helena Shomar, Marie Guillaume

Description

This defense system is composed of one gene referred to as TmtA. This system is widespread across diverse prokaryotic phyla and was experimentally validated in Escherichia coli (confers protection against phages T6 and T5).

Molecular mechanism

To our knowledge the molecular mechanism is unknown. Please update.

Example of genomic structure

The Tiamat is composed of 1 protein: TmtA.

Here is an example found in the RefSeq database:

The Tiamat system in Undibacterium parvum (GCF_003955735.1, NZ_CP034464) is composed of 1 protein: TmtA (WP_126126601.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Tiamat is detected in 326 genomes (1.43 %).

The system was detected in 251 different species.

Proportion of genome encoding the Tiamat system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Tiamat

Example 1

Experimental validation

      
graph LR;
    Millman_2022[Millman et al., 2022] --> Origin_0
    Origin_0[Bacillus cereus 
2641244160] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T6 & T5
    subgraph Title1[Reference]
        Millman_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T6
        T5
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1016/j.chom.2022.09.017
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